Stuart Peirson
BSc, PhD
Professor of Circadian Neuroscience
Circadian Neuroscience
Research Summary
My research focuses on how light regulates physiology and behaviour, with a particular interest in how our modern artificial light environment may disrupt these processes. The retina contains photoreceptors that mediate the tasks of vision as well the regulation of circadian rhythms, sleep and alertness. The central aim of my work is to understand how light information is transmitted from photoreceptor to brain to drive these responses. Research in my lab depends upon molecular biology and genomics, as well as optogenetics and chemogenetics. We also study behavioural responses including circadian rhythms, sleep and cognitive function. Photobiology, statistics and bioinformatics critically underpin our work.
Sources of Funding
Biography
I am Professor of Circadian Neuroscience and Group Leader in the fundamental neuroscience theme of the Sleep and Circadian Neuroscience Institution (SCNi). After completing my PhD in Neuroscience at the Institute of Ophthalmology UCL I moved to Imperial College to work as a postdoc. During this time I also acted as technical supervisor for the quantitative real-time PCR (qPCR) facility at Charing Cross Hospital. During my subsequent work, I contributed to the identification of the melanopsin pRGC system in humans as well as the characterisation of melanopsin signalling pathways. I was appointed as a Lecturer at Imperial College in 2005 before moving to the University of Oxford in 2006. My work has continued to focus upon characterising the signalling pathways mediating the effects of light on physiology and behaviour, with the aim of identifying novel targets for the regulation of circadian rhythms and sleep.
Key publications
-
Constant Light Desynchronises Olfactory versus Object and Visuospatial Recognition Memory Performance
Journal article
Tam SKE. et al, (2017), The Journal of Neuroscience
-
Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light
Journal article
Hankins MW. et al, (2016), PLoS Biology
-
Isoforms of Melanopsin Mediate Different Behavioral Responses to Light.
Journal article
Jagannath A. et al, (2015), Curr Biol, 25, 2430 - 2434
-
The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.
Journal article
Jagannath A. et al, (2013), Cell, 154, 1100 - 1111
-
Nonuniform distribution and spectral tuning of photosensitive retinal ganglion cells of the mouse retina
Journal article
Hughes S. et al, (2013), Current Biology, 23, 1696 - 1701
-
Meta-analysis of transcriptomic datasets identifies genes enriched in the mammalian circadian pacemaker.
Journal article
Brown LA. et al, (2017), Nucleic acids research, 45, 9860 - 9873
Recent publications
-
Methods to estimate body temperature and energy expenditure dynamics in fed and fasted laboratory mice: effects of sleep deprivation and light exposure.
Journal article
van der Vinne V. et al, (2024), J Comp Physiol B, 194, 369 - 381
-
Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research.
Journal article
Lucas RJ. et al, (2024), PLoS Biol, 22
-
Continuous home cage monitoring of activity and sleep in mice during repeated paroxetine treatment and discontinuation.
Journal article
Collins HM. et al, (2023), Psychopharmacology (Berl), 240, 2403 - 2418
-
Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice
Preprint
Guillaumin MCC. et al, (2023)
-
Re-examining extreme sleep duration in bats: implications for sleep phylogeny, ecology and function.
Journal article
Harding CD. et al, (2022), Sleep
-
A Systematic comparison of optogenetic approaches to visual restoration
Journal article
HANKINS M. et al, (2022), Molecular Therapy - Methods and Clinical Development
-
The hypothalamic link between arousal and sleep homeostasis in mice.
Journal article
Yamagata T. et al, (2021), Proc Natl Acad Sci U S A, 118
-
Light regulated SIK1 remodels the synaptic phosphoproteome to induce sleep
Preprint
Taylor L. et al, (2021)
-
Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory.
Journal article
Tam SKE. et al, (2021), Proc Natl Acad Sci U S A, 118
-
Zfhx3 modulates retinal sensitivity and circadian responses to light.
Journal article
Hughes S. et al, (2021), FASEB J, 35
Rodent Toolbox v2.xlsx
- Rodent Toolbox v2.xlsx
- Microsoft Office - Spreadsheet 140.2 KB