Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The Experimental and Clinical Sleep Medicine group is jointly led by Professor Colin Espie and Professor Simon Kyle. Our research aims to 1) elucidate the mechanisms underpinning chronic sleep disruption; 2) understand the role of sleep disruption in driving adverse health outcomes; and 3) develop interventions to treat sleep and circadian rhythm disruption. We conduct human experimental and clinical studies on sleep and disorders of sleep. Our research programme is supported by the National Institute of Health Research through the Oxford Biomedical Research Centre, Health Technology Assessment Programme, and Efficacy and Mechanisms Evaluation Programme, and the Dr. Mortimer and Theresa Sackler Foundation, amongst others.


We are interested in investigating the predispositional, precipitating and perpetuating factors contributing to sleep disorders, as well as understanding the efficacy and mechanisms of action of cognitive behavioural interventions. We see sleep as a transdiagnostic process, across the lifespan, and so regard sleep health and sleep improvement as a central mediator of physical, emotional and cognitive wellbeing. 

Experimental & Clinical Sleep Medicine is a cross-cutting theme which focuses particularly on two of the strategic aims of the Sleep and Circadian Neuroscience Institute (SCNi).

  1. To apply the knowledge gained from our empirical research to deliver evidence-based and condition specific therapeutics to address sleep and circadian rhythm disruption.
  2. To transfer this knowledge to the broader academic, clinical, public and patient communities using multiple channels of engagement. 


The Wellcome Trust 

Sleep and Circadian Neuroscience Institute

Education Endowment Foundation

Dr Mortimer & Theresa Sackler Foundation



John Fell Fund

Innovate UK

Big Health

Our team

Selected publications