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Contact information

Email
simon.kyle@ndcn.ox.ac.uk

Simon Kyle

MA (First Class Hons.), PhD

Professor of Experimental and Clinical Sleep Research

Programme Director, The Oxford Online Programme in Sleep Medicine
Co-Director, Experimental and Clinical Sleep Medicine
Honorary Member, Department of Psychiatry
Senior Research Fellow, Somerville College
Theme Co-Lead, Better Sleep, NIHR Oxford Health Biomedical Research Centre

Sleep, sleep disorders and their treatment

I have specific research interests in the aetiology and management of sleep disturbance and the interaction between sleep disturbance and mental health.

My research is funded by The National Institute for Health and Care Research (NIHR) Oxford Health Biomedical Research Centre (BRC), Health Technology Assessment (HTA) Programme, Programme Grants for Applied Research (PGfAR), Efficacy and Mechanisms Evaluation (EME) Programme and the Wellcome Trust.

Websites

Kavli Institute for Nanoscience Discovery
Research centre

Key publications

Emotional Processing Following Digital Cognitive Behavioral Therapy for Insomnia in People With Depressive Symptoms: A Randomized Clinical Trial.

Tamm S. et al, (2025), JAMA Netw Open, 8

Clinical effectiveness of DREAMS START (Dementia Related Manual for Sleep; Strategies for Relatives) versus usual care for people with dementia and their carers: a single-masked, phase 3, parallel-arm, superiority randomised controlled trial

KYLE S., (2024), The Lancet Healthy Longevity

The sleep-circadian interface: a window into mental disorders

Meyer N. et al, (2024), Proceedings of the National Academy of Sciences of USA

The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023.

Riemann D. et al, (2023), J Sleep Res, 32

Clinical and cost-effectiveness of nurse-delivered sleep restriction therapy for insomnia in primary care (HABIT): a pragmatic, superiority, open-label, randomised controlled trial

KYLE S., (2023), The Lancet

The effect of sleep continuity disruption on multimodal emotion processing and regulation: a laboratory-based, randomized, controlled experiment in good sleepers.

Reid M. et al, (2022), Journal of Sleep Research

The effect of sleep restriction therapy for insomnia on sleep pressure and arousal: a randomized controlled mechanistic trial.

Maurer LF. et al, (2022), Sleep, 45

Biological and clinical insights from genetics of insomnia symptoms.

Lane JM. et al, (2019), Nat Genet, 51, 387 - 393

Sleep and cognitive performance: cross-sectional associations in the UK Biobank.

Kyle SD. et al, (2017), Sleep Med, 38, 85 - 91

A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automated media-rich web application.

Espie CA. et al, (2012), Sleep, 35, 769 - 781

Recent publications

Insights from nine nights of self-applied, low-density sleep EEG during sleep restriction therapy: a proof-of-concept evaluation

Stanyer EC. et al, (2026)

Untangling the mechanisms of sleep restriction therapy.

Stanyer EC. et al, (2026), Sleep, 49

Sleep and circadian health in the UK Biobank: Report on the 2023 sleep questionnaire enhancement.

Tse KYK. et al, (2026), Sleep

The DREAMS START intervention for sleep in dementia: Long-term follow-up of a randomized controlled trial.

Rapaport P. et al, (2026), Alzheimers Dement, 22

Digital Cognitive Behavioural Therapy for Insomnia Compared to Sleep Health Education in Older Adults With Mild Cognitive Impairment and Insomnia: A Feasibility Randomised Controlled Trial.

Hoyos CM. et al, (2026), J Sleep Res

Sleep Improvement for Metabolic Health: A Feasibility Trial of a Digital Sleep Treatment in People With Insomnia and Non-Diabetic Hyperglycaemia.

Sharman R. et al, (2026), J Sleep Res

The clinical and cost-effectiveness of improving sleep via carer delivered strategies in people with dementia: the DREAMS START parallel multi-centre RCT.

Rapaport P. et al, (2026), Health Technol Assess, 30, 1 - 26

Associations between shift work patterns and sleep disturbance: an analysis of cross-sectional data from UK Biobank.

Li X. et al, (2026), BMJ Open, 16

Longitudinal cardiorespiratory wearable sleep staging in the home.

Davidson S. et al, (2026), Front Neurosci, 20

SHIFT WORK SLEEP DISORDER-THE SHIFT-SLEEP PROGRAMME OF WORK

Sugavanam T. et al, (2026), SLEEP MEDICINE, 138