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The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies

Journal article

NIKOLAOU N. et al, (2021), The Journal of Steroid Biochemistry and Molecular Biology, 105808 - 105808

The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1

Journal article

Barnard L. et al, (2020), The Journal of Steroid Biochemistry and Molecular Biology, 105724 - 105724

Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids

Journal article

Othonos N. et al, (2020), The Journal of Clinical Endocrinology & Metabolism

Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo.

Journal article

Nikolaou N. et al, (2020), J Endocrinol

Intestinal injury and evidence of increased gut permeability in female AKR1D1 knockout mice

Journal article

Arvaniti A. et al, (2019), Endocrine Abstracts

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.

Journal article

Nikolaou N. et al, (2019), J Steroid Biochem Mol Biol, 189, 218 - 227

Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia.

Journal article

Jones CM. et al, (2017), J Clin Endocrinol Metab, 102, 1797 - 1806

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.

Journal article

Hazlehurst JM. et al, (2016), J Clin Endocrinol Metab, 101, 103 - 113

Model systems to define the role of AKR1D1 in metabolic liver disease

Journal article

Nikolaou N. et al, (2015), Endocrine Abstracts

5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes.

Journal article

Nasiri M. et al, (2015), Endocrinology, 156, 2863 - 2871

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