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AKR1D1 knockout mice develop a sex-dependent metabolic phenotype.

Gathercole LL. et al, (2022), J Endocrinol, 253, 97 - 113

Differential activity and expression of human 5β-reductase (AKR1D1) splice variants

Appanna N. et al, (2021), Journal of Molecular Endocrinology

The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies

NIKOLAOU N. et al, (2021), The Journal of Steroid Biochemistry and Molecular Biology, 105808 - 105808

The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1

Barnard L. et al, (2020), The Journal of Steroid Biochemistry and Molecular Biology, 105724 - 105724

Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids

Othonos N. et al, (2020), The Journal of Clinical Endocrinology & Metabolism

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.

Nikolaou N. et al, (2019), J Steroid Biochem Mol Biol, 189, 218 - 227

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