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We have compared the onsets of expression of the classical visual opsins with those of the non-rod, non-cone opsins in foetal and post-natal eye tissue from mice and humans. Mouse Rgr-opsin, peropsin, encephalopsin and melanopsin are all expressed in foetal development by E11.5, unlike the murine rod and cone opsins that exhibit post-natal expression, e.g. P1 for ultraviolet cone opsin and P5 for rod opsin. Human non-rod, non-cone opsins are also all expressed early, by 8.6 weeks post-conception. The implications of these observations are discussed with regard to the possible functions of these opsins at early stages of ocular development.

Original publication

DOI

10.1016/s0014-4835(02)00300-7

Type

Journal article

Journal

Exp Eye Res

Publication Date

03/2003

Volume

76

Pages

393 - 396

Keywords

Animals, Embryonic and Fetal Development, Eye, Gene Expression Regulation, Developmental, Humans, Mice, Reverse Transcriptase Polymerase Chain Reaction, Rod Opsins