Amin Mottahedin
MSc, PhD, FHEA
Senior Research Fellow
We (Buchan's lab and Foster's lab) investigate how time-of-day affects stroke-induced brain injury. I am particularly interested in how metabolic responses to ischemia and hypoxia are affected by time of day and our circadian rhythm.
I completed my PhD in Medical Sciences from University of Gothenburg (Mallard's lab). During my studies, we revealed the mechanisms by which bacterial and viral infections exacerbate neonatal hypoxic-ischemic brain injury. After receiving an international postdoc fellowship from Swedish Research Council, I joined Mike Murphy's & Thomas Krieg's lab at University of Cambridge, where we were able to identify malonate as a potential therapeutic to reduce ischemia-reperfusion injury after stroke.
Contact information
Colleges
Recent publications
2-deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after stroke in the rat
Preprint
Boehm-Sturm P. et al, (2025)
Stroke in the Time of Circadian Medicine.
Journal article
Mergenthaler P. et al, (2024), Circ Res, 134, 770 - 790
Two different isoforms of osteopontin modulate myelination and axonal integrity.
Journal article
Nilsson G. et al, (2023), FASEB Bioadv, 5, 336 - 353
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke.
Journal article
Mottahedin A. et al, (2023), Redox Biol, 59
ND3 Cys39 in complex I is exposed during mitochondrial respiration.
Journal article
Burger N. et al, (2022), Cell Chem Biol, 29, 636 - 649.e14