Amin Mottahedin
MSc, PhD, FHEA
Senior Research Fellow
We (Buchan's lab and Foster's lab) investigate how time-of-day affects stroke-induced brain injury. I am particularly interested in how metabolic responses to ischemia and hypoxia are affected by time of day and our circadian rhythm.
I completed my PhD in Medical Sciences from University of Gothenburg (Mallard's lab). During my studies, we revealed the mechanisms by which bacterial and viral infections exacerbate neonatal hypoxic-ischemic brain injury. After receiving an international postdoc fellowship from Swedish Research Council, I joined Mike Murphy's & Thomas Krieg's lab at University of Cambridge, where we were able to identify malonate as a potential therapeutic to reduce ischemia-reperfusion injury after stroke.
Contact information
Colleges
Recent publications
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2-Deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after stroke in the rat
Boehm-Sturm P. et al, (2025)
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Stroke in the Time of Circadian Medicine.
Mergenthaler P. et al, (2024), Circ Res, 134, 770 - 790
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Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke
Mottahedin A. et al, (2023), Redox Biology, 59
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Two different isoforms of osteopontin modulate myelination and axonal integrity
Nilsson G. et al, (2023), FASEB BioAdvances
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Scavenger receptor CD36 governs recruitment of myeloid cells to the blood–CSF barrier after stroke in neonatal mice
Rayasam A. et al, (2022), Journal of Neuroinflammation, 19