Amin Mottahedin
MSc, PhD, FHEA
Senior Research Fellow
I work with Foster's lab at Nuffield Department of Clinical Neurosciences (NDCN) and Buchan’s lab at Radcliffe Department of Medicine to unravel the effect of circadian rhythm on stroke-induced brain injury. I am particularly interested in how metabolic responses to ischemia and hypoxia are affected by circadian rhythm.
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I worked as a veterinarian in my home country, Iran, before moving to Sweden to start my science career. I obtained a master’s degree in Infection Biology from Uppsala University and completed my PhD in Medical Sciences from University of Gothenburg (Mallard's lab). During my PhD, I investigated how infection/ inflammation affects the developing brain and exacerbates the hypoxic-ischemic brain injury. After receiving an international postdoc fellowship from Swedish Research Council, I joined Murphy's & Krieg's lab at MRC Mitochondrial Biology Unit, University of Cambridge, where we were able to identify mitochondrial succinate metabolism as a potential therapeutic target in ischemic stroke.
Contact information
Colleges
Recent publications
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Stroke in the Time of Circadian Medicine.
Journal article
Mergenthaler P. et al, (2024), Circ Res, 134, 770 - 790
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Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke
Journal article
Mottahedin A. et al, (2023), Redox Biology, 59
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Two different isoforms of osteopontin modulate myelination and axonal integrity
Journal article
Nilsson G. et al, (2023), FASEB BioAdvances
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Scavenger receptor CD36 governs recruitment of myeloid cells to the blood–CSF barrier after stroke in neonatal mice
Journal article
Rayasam A. et al, (2022), Journal of Neuroinflammation, 19
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ND3 Cys39 in complex I is exposed during mitochondrial respiration.
Journal article
Burger N. et al, (2022), Cell Chem Biol, 29, 636 - 649.e14