BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes.
Kim A. et al, (2021), Elife, 10
Nanoscale Amperometry Reveals that Only a Fraction of Vesicular Serotonin Content is Released During Exocytosis from Beta Cells
Hatamie A. et al, (2021), Angewandte Chemie
Nanoscale Amperometry Reveals that Only a Fraction of Vesicular Serotonin Content is Released During Exocytosis from Beta Cells.
Hatamie A. et al, (2020), Angew Chem Int Ed Engl
Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes.
Oduori OS. et al, (2020), J Clin Invest
The vascular architecture of the pancreatic islets: A homage to August Krogh.
Muratore M. et al, (2020), Comp Biochem Physiol A Mol Integr Physiol, 252