Patrik Rorsman
BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Recent publications
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Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes.
Journal article
Oduori OS. et al, (2020), J Clin Invest
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The vascular architecture of the pancreatic islets: A homage to August Krogh.
Journal article
Muratore M. et al, (2020), Comp Biochem Physiol A Mol Integr Physiol, 252
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Release of insulin granules by simultaneous, high-speed correlative SICM-FCM.
Journal article
Bednarska J. et al, (2020), J Microsc
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Response to Comment on Satin et al. "Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes 2020;69:830-836.
Journal article
Satin LS. and Rorsman P., (2020), Diabetes, 69, e12 - e13
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Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in mice.
Journal article
Chanclón B. et al, (2020), Int J Obes (Lond)
ORCID
0000-0001-7578-0767