Patrik Rorsman
BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Recent publications
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Dehydration-induced AVP stimulates glucagon release and ketogenesis.
Journal article
Hill TG. et al, (2025), Am J Physiol Endocrinol Metab
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Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells.
Journal article
Hamilton A. et al, (2025), Diabetes, 74, 53 - 64
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Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.
Conference paper
Hill TG. et al, (2024), Nat Metab
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Author Correction: Every islet matters: improving the impact of human islet research
Journal article
Gloyn AL. et al, (2024), Nature Metabolism
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Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model.
Journal article
Jaffredo M. et al, (2024), Diabetes
ORCID
0000-0001-7578-0767