Patrik Rorsman
BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Recent publications
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Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.
Conference paper
Hill TG. et al, (2024), Nat Metab
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Author Correction: Every islet matters: improving the impact of human islet research
Journal article
Gloyn AL. et al, (2024), Nature Metabolism
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Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model.
Journal article
Jaffredo M. et al, (2024), Diabetes
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The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets.
Journal article
Acreman S. et al, (2024), iScience, 27
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An unclear role for the GLP-1 metabolite GLP-1(9–36) in human islet physiology. Reply to Matveyenko A, Vella A [letter]
Journal article
Gandasi NR. and Rorsman P., (2024), Diabetologia
ORCID
0000-0001-7578-0767