BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells.
Armour SL. et al, (2023), Diabetes, 72, 1446 - 1459
Platelet-derived lipids promote insulin secretion of pancreatic β cells.
Karwen T. et al, (2023), EMBO Mol Med
History of key regulatory peptide systems and perspectives for future research
Chen D. et al, (2023), Journal of Neuroendocrinology
Metabolic Messengers: glucagon.
MacDonald PE. and Rorsman P., (2023), Nat Metab
Electrophysiological characterisation of iPSC-derived human β-like cells and anSLC30A8disease model.
Jaffredo M. et al, (2023)