BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.
Veprik A. et al, (2022), Commun Biol, 5
Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue
Bauzá-Thorbrügge M. et al, (2022)
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.
Dai X-Q. et al, (2022), Cell Metab, 34, 256 - 268.e5
Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes.
Kim A. et al, (2021), Elife, 10
Nanoscale Amperometry Reveals that Only a Fraction of Vesicular Serotonin Content is Released During Exocytosis from Beta Cells
Hatamie A. et al, (2021), Angewandte Chemie