BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Response to Comment on Satin et al. "Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes 2020;69:830-836.
Satin LS. and Rorsman P., (2020), Diabetes, 69, e12 - e13
Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in mice.
Chanclón B. et al, (2020), Int J Obes (Lond)
'Resistance is futile?' - paradoxical inhibitory effects of KATP channel closure in glucagon-secreting α-cells.
Zhang Q. et al, (2020), J Physiol
Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet
KELLARD J. et al, (2020), Molecular Metabolism
A method for the generation of human stem cell-derived alpha cells.
Peterson QP. et al, (2020), Nat Commun, 11