Patrik Rorsman

BM, PhD, FRS, FMedSci

Professor of Diabetic Medicine

Diabetes, Insulin secretion

We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.

Recent publications

Release of insulin granules by simultaneous, high-speed correlative SICM-FCM.
Journal article

Bednarska J. et al, (2020), J Microsc
Response to Comment on Satin et al. "Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes 2020;69:830-836.
Journal article

Satin LS. and Rorsman P., (2020), Diabetes, 69, e12 - e13
Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in mice.
Journal article

Chanclón B. et al, (2020), Int J Obes (Lond)
'Resistance is futile?' - paradoxical inhibitory effects of KATP channel closure in glucagon-secreting α-cells.
Journal article

Zhang Q. et al, (2020), J Physiol
Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet
Journal article

KELLARD J. et al, (2020), Molecular Metabolism

More publications

ORCID

0000-0001-7578-0767