Patrik Rorsman
BM, PhD, FRS, FMedSci
Professor of Diabetic Medicine
Diabetes, Insulin secretion
We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.
Recent publications
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Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells.
Journal article
Armour SL. et al, (2023), Diabetes, 72, 1446 - 1459
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Platelet-derived lipids promote insulin secretion of pancreatic β cells.
Journal article
Karwen T. et al, (2023), EMBO Mol Med
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History of key regulatory peptide systems and perspectives for future research
Journal article
Chen D. et al, (2023), Journal of Neuroendocrinology
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Metabolic Messengers: glucagon.
Journal article
MacDonald PE. and Rorsman P., (2023), Nat Metab
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Electrophysiological characterisation of iPSC-derived human β-like cells and anSLC30A8disease model.
Preprint
Jaffredo M. et al, (2023)
ORCID
0000-0001-7578-0767