Ma'ayan Semo
My research work has broadly focussed on the neurobiology of visual function. This has encompassed work on restoring visual function using cellular transplantations and genetic modifications, as well as investigation of retinal control of irradiance detection tasks. This research has gained me diverse experience in many types of experimental techniques: molecular biology (QPCR, RNAseq); histology (immunohistochemistry, confocal microscopy); cell culture (human embryonic and induced pluripotent stem cells, retinal progenitor cells, differentiation of neurons); and electrophysiology (electroretinogram recordings and multi-electrode arrays.
Recent publications
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Rodent models in translational circadian photobiology.
Tir S. et al, (2022), 273, 97 - 116
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Splice-Modulating Oligonucleotide QR-110 Restores CEP290 mRNA and Function in Human c.2991+1655A>G LCA10 Models.
Dulla K. et al, (2018), Mol Ther Nucleic Acids, 12, 730 - 740
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Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity.
Zarouchlioti C. et al, (2018), Am J Hum Genet, 102, 528 - 539
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Efficacy and Safety of Human Retinal Progenitor Cells.
Semo M. et al, (2016), Transl Vis Sci Technol, 5
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Retrograde Melanopsin Signaling Increases With Age in Retinal Degenerate Mice Lacking Rods and the Majority of Cones.
Semo M. et al, (2016), Invest Ophthalmol Vis Sci, 57, 115 - 125