Contact information
01865 618693
New Biochemistry Building University of Oxford South Parks Road Oxford OX1 3QU
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Aarti Jagannath
DPhil
Associate Professor
- Researching the molecular mechanisms underlying sleep and circadian rhythm regulation
- Group Leader
- BBSRC David Phillips Fellow
Circadian Biology
I am a BBSRC David Phillips Fellow at the Sleep and Circadian Neuroscience Institute within the Nuffield Department of Clinical Neuroscience. My group researches the molecular mechanisms that regulate circadian clock entrainment.
All organisms show 24h rhythms in their physiology and behaviour, orchestrated by a circadian clock that coordinates internal time with the external world. Our research aims to understand the molecular mechanisms by which the circadian clock picks up cues from the external environment and is set to the right time. Some of our ongoing projects are listed below.
1) The role of Salt Inducible Kinases in regulating sleep and circadian rhythms:
2) The interaction of sleep and circadian signalling pathways:
3) The effect of light and other environmental inputs on the molecular clockwork:
About me: I read for a DPhil on the mechanisms of RNA interference at Brasenose college, Oxford. I subsequently joined the Sleep and Circadian Neuroscience Institute as a Roche Post-Doctoral Fellow in to work on the circadian clock and have stayed in the unit to become a group leader. I was awarded the L’Oreal Women in Science Fellowship in 2015 and I am the founder of a spin-out company, Circadian Therapeutics, that translates some of our research into the clinical arena. I am also a mother of two and am a passionate advocate for women in STEM careers.
Enquiries from potential DPhil students welcome.
Research groups
Websites
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Kavli Institute for Nanoscience Discovery
Research centre
Key publications
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Journal article
Jagannath A. et al, (2013), Cell, 154, 1100 - 1111
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Journal article
JAGANNATH A. et al, (2021), Nature Communications
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Journal article
Sanghani HR. et al, (2020), Mol Psychiatry
Recent publications
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Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection.
Journal article
Taylor L. et al, (2022), iScience
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Influence of socioeconomic status and stress over quality of sleep: A systematic review
Conference paper
Sosso FAE. et al, (2021), INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE, 28, S27 - S28
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Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
Journal article
JAGANNATH A. et al, (2021), Nature Communications
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Circadian regulation of SARS-CoV-2 infection in lung epithelial cells.
Journal article
Zhuang X. et al, (2021), bioRxiv
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Cold-induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm.
Journal article
Fischl H. et al, (2020), EMBO J, 39