Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.
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Evaluating the potential of novel genetic approaches for the treatment of Duchenne muscular dystrophy.
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From diagnosis to therapy in Duchenne muscular dystrophy.
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Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.
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Isolation, structural identification, synthesis, and pharmacological profiling of 1,2-trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromid
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Surrogate gene therapy for muscular dystrophy
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Davies KE. and Chamberlain JS., (2019), Nature Medicine, 25, 1473 - 1474
Neuronal over-expression of OXR1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo
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The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy.
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Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing.
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Regenerative biomarkers for Duchenne muscular dystrophy
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Guiraud S. and Davies KE., (2019), Neural Regeneration Research, 14, 1317 - 1320
Micro-dystrophin Genes Bring Hope of an Effective Therapy for Duchenne Muscular Dystrophy
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Davies KE. and Guiraud S., (2019), Molecular therapy : the journal of the American Society of Gene Therapy, 27, 486 - 488
A Phase 1b Trial to Assess the Pharmacokinetics of Ezutromid in Pediatric Duchenne Muscular Dystrophy Patients on a Balanced Diet.
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Embryonic myosin is a regeneration marker to monitor utrophin-based therapies for DMD.
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Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model
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Micro-utrophin Improves Cardiac and Skeletal Muscle Function of Severely Affected D2/mdx Mice.
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Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders
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