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Rod- and cone-opsin specific antibodies were used in an attempt to immunolabel remaining photoreceptor cells in the mutant rd (retinal degeneration) mouse retina. We identified a region-specific distribution in the pattern of photoreceptor degeneration, with the dorsal retina showing markedly less photoreceptor degeneration than the ventral retina. All rod and cone immunoreactive cells disappeared in the ventral retina by 100-120 days of age. By contrast, both cone and a small number of rod immunopositive cells were identified in the dorsal retina at this time. By 200 days all rod immunoreactive cells had disappeared. At 360 days numerous cone immunoreactive cells remained within a restricted region of the dorsal retina. As rd mice show unattenuated circadian responses to light, these remaining photoreceptor cells within the dorsal retina become candidates for the regulation of circadian physiology by light.

Type

Journal article

Journal

Neurosci Lett

Publication Date

24/02/1995

Volume

187

Pages

33 - 36

Keywords

Age Factors, Aging, Animals, Circadian Rhythm, Immunohistochemistry, Mice, Mice, Inbred C57BL, Photic Stimulation, Retinal Cone Photoreceptor Cells, Retinal Degeneration