Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

New vaccination strategies that induce the cellular arm of the immune response are needed for the development of effective prophylactic and therapeutic vaccines against a number of intracellular pathogens. DNA vaccines, recombinant viral vectors and recombinant proteins are all effective antigen delivery systems for inducing cellular immunity; however, when used alone, the levels of specific responses they induce are low. Prime-boost immunization strategies involve using two different vaccines, each encoding the same antigen, some weeks apart. Such strategies have been shown to enhance cellular immunity in several different animal and disease models.


Journal article


Curr Opin Mol Ther

Publication Date





23 - 27


AIDS Vaccines, Animals, Antigens, BCG Vaccine, Communicable Disease Control, Communicable Diseases, HIV Infections, Humans, Immunity, Cellular, Immunization, Immunization, Secondary, Malaria, Malaria Vaccines, Tuberculosis, Pulmonary