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Optical coherence tomography angiography (OCT-A) retinal imaging enables in vivo visualization of the retinal microvasculature that is developmentally related to the brain and can offer insight on cerebrovascular health. We investigated retinal phenotypes and neuroimaging markers of small vessel disease (SVD) in individuals with obstructive sleep apnoea (OSA). We enrolled 44 participants (mean age 50.1 ± SD 9.1 years) and performed OCT-A imaging before and after continuous positive airway pressure (CPAP) therapy. Pre-treatment analyses using a generalized estimating equations model adjusted for relevant covariates, revealed perivascular spaces (PVS) volume in basal ganglia associated with greater foveal vessel density (fVD) (p-value 

Original publication

DOI

10.1177/0271678x241291958

Type

Journal article

Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Publication Date

04/2025

Volume

45

Pages

690 - 702

Addresses

Centre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh, UK.

Keywords

Retinal Vessels, Humans, Sleep Apnea, Obstructive, Tomography, Optical Coherence, Continuous Positive Airway Pressure, Phenotype, Adult, Middle Aged, Female, Male, Microvessels