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Family history is an important independent risk factor for coronary artery disease (CAD), and identification of susceptibility genes for this common, complex disease is a vital goal. Although there has been considerable success in identifying genetic variants that influence well-known risk factors, such as cholesterol levels, progress in unearthing novel CAD genes has been slow. However, advances are now being made through the application of large-scale, systematic, genome-wide approaches. Recent findings particularly highlight the link between CAD and inflammation and immunity, and highlight the biological insights to be gained from a genetic understanding of the world's biggest killer.

Original publication




Journal article


Nat Rev Genet

Publication Date





163 - 173


Animals, Coronary Artery Disease, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Humans, Inflammation, Sequence Analysis, DNA