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Type 2 diabetes is a progressive disorder, but exactly how the progression occurs remains unknown. In this issue of Cell Metabolism, Zhang et al. (2019) present evidence that diabetes, via hyperglycemia, leads to aberrant insertion of a mitochondrial ion channel in the plasma membrane, rendering it leaky to key intracellular signaling molecules with resultant suppression of insulin secretion.

Original publication

DOI

10.1016/j.cmet.2018.12.015

Type

Journal article

Journal

Cell Metab

Publication Date

08/01/2019

Volume

29

Pages

1 - 2

Keywords

Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Insulin Secretion, Insulin-Secreting Cells, Mitochondria, Voltage-Dependent Anion Channel 1