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Myelin is important for the normal development and healthy function of the nervous system. Recent developments in MRI acquisition and tissue modelling aim to provide a better characterization and more specific markers for myelin. This allows for specific monitoring of myelination longitudinally and non-invasively in the healthy brain as well as assessment of treatment and intervention efficacy. Here we offer a non-technical review of MRI techniques developed to specifically monitor myelin such as magnetization transfer (MT) and myelin water imaging (MWI). We further summarize recent studies that employ these methods to measure myelin in relation to development and aging, learning and experience, and neuropathology and psychiatric disorders. This article is protected by copyright. All rights reserved.

Original publication

DOI

10.1002/dneu.22552

Type

Journal article

Journal

Developmental neurobiology

Publication Date

30/10/2017

Addresses

Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.