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In clinical trials recombinant-modified vaccinia virus Ankara expressing the Mycobacterium tuberculosis antigen 85A (MVA85A) induces approximately 10 times more effector T cells than any other recombinant MVA vaccine. We have found that in BCG primed subjects MVA85A vaccination reduces transforming growth factor beta 1 (TGF-beta1) mRNA in peripheral blood lymphocytes and reduces TGF-beta1 protein in the serum, but increases IFN-gamma ELISPOT responses to the recall antigen SK/SD. TGF-beta1 is essential for the generation of regulatory T cells and we see a correlation across vaccinees between CD4+CD25hiFoxP3+ cells and TGF-beta1 serum levels. This apparent ability to counteract regulatory T cell effects suggests a potential use of MVA85A as an adjuvant for less immunogenic vaccines.

Original publication

DOI

10.1016/j.vaccine.2008.07.040

Type

Journal article

Journal

Vaccine

Publication Date

26/09/2008

Volume

26

Pages

5269 - 5275

Keywords

Acyltransferases, Adolescent, Adult, Antigens, Bacterial, BCG Vaccine, Down-Regulation, Female, Forkhead Transcription Factors, Humans, Interferon-gamma, Leukocytes, Mononuclear, Male, Middle Aged, Mycobacterium tuberculosis, Transforming Growth Factor beta1, Tuberculosis Vaccines