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We have identified Ngef as a novel member of the family of Dbl genes. Many members of this family have been shown to function as guanine nucleotide exchange factors for the Rho-type GTPases. Ngef is predominantly expressed in brain, with the strongest signal in the caudate nucleus, a region associated with the control of movement. Ngef contains a translated trinucleotide repeat, a polyglutamic acid stretch interrupted by a glycine. We have localized the Ngef gene to mouse chromosome 1 and the human homologue of Ngef to human chromosome 2q37. We have shown in preliminary experiments that Ngef has transforming potential in cell culture and is able to induce tumors in nude mice.

Original publication




Journal article



Publication Date





53 - 61


3T3 Cells, Amino Acid Sequence, Animals, Base Sequence, Blotting, Northern, Caudate Nucleus, Chromosome Mapping, Chromosomes, Human, Pair 2, DNA, Complementary, Gene Expression, Guanine Nucleotide Exchange Factors, Humans, In Situ Hybridization, Fluorescence, Mice, Mice, Nude, Molecular Sequence Data, Neoplasms, Experimental, Proto-Oncogene Proteins, RNA, Messenger, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Tissue Distribution